Cardiovascular Health Research Unit

Barbara McKnight, PhD

Professor, Biostatistics

bmcku.washington.edu

Education

BA, Mathematics, Pomona College, Claremont, CA, 1976
MS, Statistics, University of Wisconsin, Madison, WI, 1979
PhD, Statistics, University of Wisconsin, Madison, WI, 1981


Interests

Statistical methods in epidemiology and clinical trials
Human genetics
Survival analysis


Honors

School of Public Health Outstanding Teaching Award, University of Washington, Seattle, Washington 1988, 2006
Team Science Award, American Association for Cancer Research, 2011


Publications

CM Sitlani, KM Rice, T Lumley, B McKnight, LA Cupples, CL Avery, R Noordam, BHC Stricker, EA Whitsel, and BM Psaty. Generalized estimating equations for genome-wide association studies using longitudinal phenotype data. Statistics in Medicine, 34:118-130, 2015. PMID:25297442

RN Lemaitre, IB King, K Rice, B McKnight, N Sotoodehnia, TD Rea, CO Johnson, TE Raghunathan, LA Cobb, D Mozaffarian, DS Siscovick. Erythrocyte very long-chain saturated fatty acids associated with lower risk of incident sudden cardiac arrest. 2014-10-01. PMID:25107579

Floyd JS, Sitlani CM, Wiggins, KL, Wallace E, Suchy-Dicey A, Carnethon MR, Siscovick DS, Sotoodehnia N, Heckbert SR, McKnight B, Rice K, Psaty BM. Variation in resting heart rate over four years and the risks of myocardial infarction and death among older adults. Heart, published online Sep 11, 2014. doi: 10.1136/heartjnl-2014-306046. PMID:25214500

Fretts AM, Mozaffarian D, Siscovick DS, Djousse L, Heckbert SR, King IB, McKnight B, Sitlani C, Sacks FM, Song X, Sotoodehnia N, Spiegelman D, Wallace ER, Lemaitre RN. Plasma phospholipid saturated fatty acids and incident atrial fibrillation: the Cardiovascular Health Study.  J Am Heart Assoc. 2014 Jun 26;3(3).  PMID:24970268

Fretts AM, Howard BV, McKnight B, Duncan GE, Beresford SA, Mete M, Zhang Y, Siscovick DS. Life's Simple 7 and Incidence of Diabetes Among American Indians: The Strong Heart Family Study. Diabetes Care. 2014: May 7. PMID:24804696

RN Lemaitre, CO Johnson, S Hesselson, N Sotoodhenia, B McKnight, CM Sitlani, TD Rea, IB King, PY Kwok, A Mak, G Li, J Brody, E Larson, D Mozaffarian, BM Psaty, A Huertas-Vazquez, JC Tardif, CM Albert, LP Lyytikäinen, DE Arking, S Kääb, HV Huikuri, BP Krijthe, M Eijgelsheim, YA Wang, K Reinier, T Lehtimäki, SL Pulit, R Brugada, M Müller-Nurasyid, CH Newton-Cheh, PJ Karhunen, BH Stricker, P Goyette, JI Rotter, SS Chugh, A Chakravarti, X Jouven, DS Siscovick. Common variation in fatty acid metabolic genes and risk of incident sudden cardiac arrest. 2014-03-01. PMID:24418166

Lin H, Sinner MF, Brody JA, Arking DE, Lunetta KL, Rienstra M, Lubitz SA, Magnani JW, Sotoodehnia N, McKnight B, McManus DD, Boerwinkle E, Psaty BM, Rotter JI, Bis JC, Gibbs RA, Muzny D, Kovar CL, Morrison AC, Gupta M, Folsom AR, Kääb S, Heckbert SR, Alonso A, Ellinor PT, Benjamin EJ; on behalf of the CHARGE Atrial Fibrillation Working Group. Targeted sequencing in candidate genes for atrial fibrillation: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Targeted Sequencing Study. Heart Rhythm. 2013 Nov 14. doi:pii: S1547-5271(13)01316-7. 10.1016/j.hrthm.2013.11.012.  PMID:24239840

Chubak J, Boudreau DM, Wirtz HS, McKnight B, Weiss NS. Threats to validity of nonrandomized studies of postdiagnosis exposures on cancer recurrence and survival. J Natl Cancer Inst. 2013 Oct 2;105(19):1456-62.  PMID:23940288

Smith NL, Blondon M, Wiggins KL, Harrington LB, van Hylckama Vlieg A, Floyd JS, Hwang M, Bis JC, McKnight B, Rice KM, Lumley T, Rosendaal FR, Heckbert SR, Psaty BM. Lower Risk of Cardiovascular Events in Postmenopausal Women Taking Oral Estradiol Compared With Oral Conjugated Equine Estrogens. JAMA Intern Med. 2013 Sep 30. doi: 10.1001/jamainternmed.2013.11074.  PMID:24081194

Sabater-Lleal M, Huang J, Chasman D, et. al. J. Multiethnic meta-analysis of genome-wide association studies in  >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. Circulation. 2013 Sep 17;128(12):1310-24. doi: 10.1161/CIRCULATIONAHA.113.002251.  PMID:23969696

Liu CT, Monda KL, Taylor KC, et. al. Genome-wide association of body fat distribution in African ancestry populations suggests new loci. PLoS Genet. 2013;9(8):e1003681. doi: 10.1371/journal.pgen.1003681. Epub 2013 Aug 15 PMID:23966867

Blondon M, Wiggins KL, Van Hylckama Vlieg A, McKnight B, Psaty BM, Rice KM, Heckbert SR, Smith NL. Smoking, postmenopausal hormone therapy and the risk of venous thrombosis: a population-based, case-control study. Br J Haematol. 2013 Nov;163(3):418-20. doi: 10.1111/bjh.12508. Epub 2013 Aug 8. PMID:23927442

Thacker EL, McKnight B, Psaty BM, Longstreth WT Jr, Sitlani CM, Dublin S, Arnold AM, Fitzpatrick AL, Gottesman RF, Heckbert SR. Atrial fibrillation and cognitive decline: a longitudinal cohort study. Neurology. 2013 Jul 9;81(2):119-25. doi: 10.1212/WNL.0b013e31829a33d1.  PMID:23739229

van Meurs JB, Pare G, Schwartz SM, Hazra A, Tanaka T, Vermeulen SH, Cotlarciuc I, Yuan X, Mälarstig A, Bandinelli S, Bis JC, Blom H, Brown MJ, Chen C, Chen YD, Clarke RJ, Dehghan A, Erdmann J, Ferrucci L, Hamsten A, Hofman A, Hunter DJ, Goel A, Johnson AD, Kathiresan S, Kampman E, Kiel DP, Kiemeney LA, Chambers JC, Kraft P, Lindemans J, McKnight B, Nelson CP, O'Donnell CJ, Psaty BM, Ridker PM, Rivadeneira F, Rose LM, Seedorf U, Siscovick DS, Schunkert H, Selhub J, Ueland PM, Vollenweider P, Waeber G, Waterworth DM, Watkins H, Witteman JC, den Heijer M, Jacques P, Uitterlinden AG, Kooner JS, Rader DJ, Reilly MP, Mooser V, Chasman DI, Samani NJ, Ahmadi KR. Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease. Am J Clin Nutr. 2013 Sep;98(3):668-76. doi: 10.3945/ajcn.112.044545. Epub 2013 Jul 3. PubMed PMID: 23824729. PMID:23824729

Lowry SJ, Chubak J, Press OW, McKnight B, Weiss NS. Risk of non-Hodgkin lymphoma in relation to tricyclic antidepressant use. Ann Epidemiol. 2013 Jun;23(6):349-54. doi: 10.1016/j.annepidem.2013.04.006.  PMID:23683711

Monda KL, Chen GK, Taylor KC, et al. A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet. 2013 Jun;45(6):690-6. doi: 10.1038/ng.2608.  PMID:23583978

Sim X, Jensen RA, Ikram MK, et. al. Genetic loci for retinal arteriolar microcirculation. PLoS One. 2013 Jun 12;8(6):e65804. doi: 10.1371/journal.pone.0065804. Print 2013. PubMed PMID: 23776548; PMID:23776548

Resler AJ, Malone KE, Johnson LG, Malkki M, Petersdorf EW, McKnight B, Madeleine MM. Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study. BMC Cancer. 2013 May 1;13:219. doi: 10.1186/1471-2407-13-219.  PMID:23634849

Berndt SI, Gustafsson S, Mägi R, et. al. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet. 2013 May;45(5):501-12. doi: 10.1038/ng.2606.  PMID:23563607

Wu, J.H.Y., Lemaitre,R.N., Manichaikul, A., Guan, W., Tanaka, T., Foy, M., Kabagambe, E.K., Djousse, L., Siscovick, D., Fretts, A.M.,  Johnson, C., King, I.B., Psaty, B.M., McKnight, B., Rich, S.S., Chen, Y.I., Nettleton, J.A., Tang, W.,  Bandinelli, S., Jacobs, D.R., Browning, B.L., Laurie, C.C., Gu, X., Tsai, M.Y., Steffen, L.M., Ferrucci, L., Fornage, M., Mozaffarian, D. Genome-Wide Association Study Identifies Novel Loci Associated With Concentrations of Four Plasma Phospholipid Fatty Acids in the De Novo Lipogenesis Pathway: Results from the CHARGE Consortium. Circulation: Cardiovascular Genetics. 2013 Apr; 6(2): 171-83.  PMID:23362303

Perry JR, Corre T, Esko T, et. al.  A genome-wide association study of early menopause and the combined impact of identified variants. Hum Mol Genet. 2013 Apr 1;22(7):1465-72. doi: 10.1093/hmg/dds551.  PMID:23307926

Blondon M, Wiggins KL, McKnight B, Psaty BM, Rice KM, Heckbert SR, Smith NL. The association of smoking with venous thrombosis in women. A population-based, case-control study. Thromb Haemost. 2013 May;109(5):891-6. doi: 10.1160/TH12-10-0732.  PMID:23467568

Common variation in fatty acid genes and resuscitation from sudden cardiac arrest. Johnson CO, Lemaitre RN, Fahrenbruch CE, Hesselson S, Sotoodehnia N, McKnight B, Rice KM, Kwok PY, Siscovick DS, Rea TD. Circ Cardiovasc Genet. 2012 Aug 1;5(4):422-9. doi: 10.1161/CIRCGENETICS.111.961912. Epub 2012 Jun 1. Erratum in: Circ Cardiovasc Genet. 2013 Feb;6(1):e1. PMID:22661490

Jensen RA, Sim X, Li X, Cotch MF, et. al.  Genome-wide association study of retinopathy in individuals without diabetes. PLoS One. 2013;8(2):e54232. doi: 10.1371/journal.pone.0054232.  PMID:23393555

Fretts AM, Mozaffarian D, Siscovick DS, Heckbert SR, McKnight B, King IB, Rimm EB, Psaty BM, Sacks FM, Song X, Spiegelman D, Lemaitre RN.  J Am Heart Assoc. 2013 Jan 31;2(1) PMID:23525429

Holliday EG, Smith AV, Cornes BK, et al.  Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. PLoS One. 2013;8(1):e53830. doi: 10.1371/journal.pone.0053830.  PMID:23326517

Ossiander EM, Koepsell TD, McKnight B. Will the light truck bumper height-matching standard reduce deaths in cars? Accid Anal Prev. 2013 Mar;51:292-300. doi: 10.1016/j.aap.2012.12.004.  PMID:23287115

AM Fretts, BV Howard, B McKnight, GE Duncan, SA Beresford, D Calhoun, AM Kriska, KL Storti, DS Siscovick. Modest levels of physical activity are associated with a lower incidence of diabetes in a population with a high rate of obesity: the strong heart family study. 2012-08-01 PMID:22723343

RN Lemaitre, C Sitlani, X Song, IB King, B McKnight, D Spiegelman, FM Sacks, L Djoussé, EB Rimm, DS Siscovick, D Mozaffarian. Circulating and dietary α-linolenic acid and incidence of congestive heart failure in older adults: the Cardiovascular Health Study. 2012-08-01. PMID:22743310

AM Fretts, BV Howard, B McKnight, GE Duncan, SA Beresford, M Mete, S Eilat-Adar, Y Zhang, DS Siscovick. Associations of processed meat and unprocessed red meat intake with incident diabetes: the Strong Heart Family Study. 2012-03-01. PMID:22277554

Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. Lemaitre RN, Tanaka T, Tang W, et. al. PLoS Genet. 2011 Jul;7(7):e1002193. PMID:21829377

Behavior of QQ-plots and genomic control in studies of gene-environment interaction.  Voorman A, Lumley T, McKnight B, Rice K.  PLoS One. 2011 May 12;6(5):e19416. PMID:21589913

CM Sitlani, B McKnight. Relative efficiency of trend tests with misspecified genetic models in stratified analyses of case-control or cohort data. 2011-01-01. PMID:21811075