Cardiovascular Health Research Unit

David Siscovick, MD, MPH

Co-founder, Cardiovascular Health Research Unit
Professor Emeritus, Department of Medicine
Professor Emeritus, Epidemiology
Affiliate Investigator, Group Health Cooperative
Affiliate Investigator, Center for Health Studies
Affiliate Investigator, Nutrition Obesity Research Center

dsisku.washington.edu

Education

MD, University of Maryland, Baltimore, MD, 1972-1976
Internship and Residency in Internal Medicine, University of Washington, Seattle, WA, 1976-1979
Residency in Preventive Medicine, University of Washington, Seattle, WA, 1979-1981
MPH, University of Washington, Seattle, WA, 1979-1981


Interests

Cardiovascular (CVD) epidemiology
Preventative cardiology
Pharmacological epidemiology of CVD
Exercise/diet and CVD
Sudden cardiac death, epidemiology and prevention


Honors

Class of 1927 Scholarship Award, 1968
Dean's Fellowship, University of Maryland, 1974
Fellow, 10th Annual U.S. Teaching Seminar on the Epidemiology and Prevention of Cardiovascular Disease, 1978
Fellowship, Robert Wood Johnson Clinical Scholar, 1979-1981
Fellow, Student Workshop on Epidemiologic Methods, Sponsored by the Society for Epidemiologic Research, 1980
Teaching and Research Scholar, American College of Physicians, 1984-1987
American Men and Women of Science, Sixteenth Edition, 1986
NHLBI Preventive Cardiology Academic Awardee, 1986-1987
American Epidemiological Society, 1996
Western Association of Physicians, 1996


Publications

PL Wander, CM Sitlani, SE Badon, DS Siscovick, MA Williams, DA Enquobahrie. Associations of Early and Late Gestational Weight Gain with Infant Birth Size.  PMID:26093689

RN Lemaitre, IB King, EK Kabagambe, JH Wu, B McKnight, A Manichaikul, W Guan, Q Sun, DI Chasman, M Foy, L Wang, J Zhu, DS Siscovick, MY Tsai, DK Arnett, BM Psaty, L Djousse, YD Chen, W Tang, LC Weng, H Wu, MK Jensen, AY Chu, DR Jacobs, SS Rich, D Mozaffarian, L Steffen, EB Rimm, FB Hu, PM Ridker, M Fornage, Y Friedlander. Genetic loci associated with circulating levels of very long-chain saturated fatty acids. 2015-01-01. PMID:25378659

RN Lemaitre, IB King, K Rice, B McKnight, N Sotoodehnia, TD Rea, CO Johnson, TE Raghunathan, LA Cobb, D Mozaffarian, DS Siscovick. Erythrocyte very long-chain saturated fatty acids associated with lower risk of incident sudden cardiac arrest. 2014-10-01. PMID:25107579

Floyd JS, Sitlani CM, Wiggins, KL, Wallace E, Suchy-Dicey A, Carnethon MR, Siscovick DS, Sotoodehnia N, Heckbert SR, McKnight B, Rice K, Psaty BM. Variation in resting heart rate over four years and the risks of myocardial infarction and death among older adults. Heart, published online Sep 11, 2014. doi: 10.1136/heartjnl-2014-306046. PMID:25214500

Fretts AM, Mozaffarian D, Siscovick DS, Djousse L, Heckbert SR, King IB, McKnight B, Sitlani C, Sacks FM, Song X, Sotoodehnia N, Spiegelman D, Wallace ER, Lemaitre RN. Plasma phospholipid saturated fatty acids and incident atrial fibrillation: the Cardiovascular Health Study.  J Am Heart Assoc. 2014 Jun 26;3(3).  PMID:24970268

Fretts AM, Howard BV, McKnight B, Duncan GE, Beresford SA, Mete M, Zhang Y, Siscovick DS. Life's Simple 7 and Incidence of Diabetes Among American Indians: The Strong Heart Family Study. Diabetes Care. 2014: May 7. PMID:24804696

GM Lawrence, S Shulman, Y Friedlander, CM Sitlani, A Burger, B Savitsky, E Granot-Hershkovitz, T Lumley, PY Kwok, S Hesselson, D Enquobahrie, PL Wander, O Manor, DS Siscovick, H Hochner. Associations of maternal pre-pregnancy and gestational body size with offspring longitudinal change in BMI. 2014-04-01. PMID:24124160

RN Lemaitre, CO Johnson, S Hesselson, N Sotoodhenia, B McKnight, CM Sitlani, TD Rea, IB King, PY Kwok, A Mak, G Li, J Brody, E Larson, D Mozaffarian, BM Psaty, A Huertas-Vazquez, JC Tardif, CM Albert, LP Lyytikäinen, DE Arking, S Kääb, HV Huikuri, BP Krijthe, M Eijgelsheim, YA Wang, K Reinier, T Lehtimäki, SL Pulit, R Brugada, M Müller-Nurasyid, CH Newton-Cheh, PJ Karhunen, BH Stricker, P Goyette, JI Rotter, SS Chugh, A Chakravarti, X Jouven, DS Siscovick. Common variation in fatty acid metabolic genes and risk of incident sudden cardiac arrest. 2014-03-01. PMID:24418166

GM Peloso, PL Auer, JC Bis, A Voorman, AC Morrison, NO Stitziel, JA Brody, et. al. Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks. 2014-02-06. PMID:24507774

CL Avery, CM Sitlani, DE Arking, DK Arnett, JC Bis, E Boerwinkle, BM Buckley, YD Ida Chen, AJ de Craen, M Eijgelsheim, D Enquobahrie, DS Evans, I Ford, ME Garcia, V Gudnason, TB Harris, SR Heckbert, H Hochner, A Hofman, WC Hsueh, A Isaacs, JW Jukema, P Knekt, JA Kors, BP Krijthe, K Kristiansson, M Laaksonen, Y Liu, X Li, PW Macfarlane, C Newton-Cheh, MS Nieminen, BA Oostra, GM Peloso, K Porthan, K Rice, FF Rivadeneira, JI Rotter, V Salomaa, N Sattar, DS Siscovick, PE Slagboom, AV Smith, N Sotoodehnia, DJ Stott, BH Stricker, T Stürmer, S Trompet, AG Uitterlinden, C van Duijn, RG Westendorp, JC Witteman, EA Whitsel, BM Psaty. Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. 2014-02-01. PMID:23459443

PL Wander, H Hochner, CM Sitlani, DA Enquobahrie, T Lumley, GM Lawrence, A Burger, B Savitsky, O Manor, V Meiner, S Hesselson, PY Kwok, DS Siscovick, Y Friedlander. Maternal Genetic Variation Accounts in Part for the Associations of Maternal Size during Pregnancy with Offspring Cardiometabolic Risk in Adulthood. PMID:24670385

KJ Mukamal, JB Wilk, ML Biggs, MK Jensen, JH Ix, JR Kizer, RP Tracy, SJ Zieman, D Mozaffarian, BM Psaty, DS Siscovick, L Djoussé. Common FABP4 Genetic Variants and Plasma Levels of Fatty Acid Binding Protein 4 in Older Adults. 2013-11-01. PMID:24043587

van Meurs JB, Pare G, Schwartz SM, Hazra A, Tanaka T, Vermeulen SH, Cotlarciuc I, Yuan X, Mälarstig A, Bandinelli S, Bis JC, Blom H, Brown MJ, Chen C, Chen YD, Clarke RJ, Dehghan A, Erdmann J, Ferrucci L, Hamsten A, Hofman A, Hunter DJ, Goel A, Johnson AD, Kathiresan S, Kampman E, Kiel DP, Kiemeney LA, Chambers JC, Kraft P, Lindemans J, McKnight B, Nelson CP, O'Donnell CJ, Psaty BM, Ridker PM, Rivadeneira F, Rose LM, Seedorf U, Siscovick DS, Schunkert H, Selhub J, Ueland PM, Vollenweider P, Waeber G, Waterworth DM, Watkins H, Witteman JC, den Heijer M, Jacques P, Uitterlinden AG, Kooner JS, Rader DJ, Reilly MP, Mooser V, Chasman DI, Samani NJ, Ahmadi KR. Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease. Am J Clin Nutr. 2013 Sep;98(3):668-76. doi: 10.3945/ajcn.112.044545. Epub 2013 Jul 3. PubMed PMID: 23824729. PMID:23824729

Monda KL, Chen GK, Taylor KC, et al. A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet. 2013 Jun;45(6):690-6. doi: 10.1038/ng.2608.  PMID:23583978

Sim X, Jensen RA, Ikram MK, et. al. Genetic loci for retinal arteriolar microcirculation. PLoS One. 2013 Jun 12;8(6):e65804. doi: 10.1371/journal.pone.0065804. Print 2013. PubMed PMID: 23776548; PMID:23776548

Long-chain monounsaturated Fatty acids and incidence of congestive heart failure in 2 prospective cohorts. Imamura F, Lemaitre RN, King IB, Song X, Steffen LM, Folsom AR, Siscovick DS, Mozaffarian D. Circulation. 2013 Apr 9;127(14):1512-21, 1521e1-18. doi: 10.1161/CIRCULATIONAHA.112.001197. Epub 2013 Mar 13. PMID:23487436

Wu, J.H.Y., Lemaitre,R.N., Manichaikul, A., Guan, W., Tanaka, T., Foy, M., Kabagambe, E.K., Djousse, L., Siscovick, D., Fretts, A.M.,  Johnson, C., King, I.B., Psaty, B.M., McKnight, B., Rich, S.S., Chen, Y.I., Nettleton, J.A., Tang, W.,  Bandinelli, S., Jacobs, D.R., Browning, B.L., Laurie, C.C., Gu, X., Tsai, M.Y., Steffen, L.M., Ferrucci, L., Fornage, M., Mozaffarian, D. Genome-Wide Association Study Identifies Novel Loci Associated With Concentrations of Four Plasma Phospholipid Fatty Acids in the De Novo Lipogenesis Pathway: Results from the CHARGE Consortium. Circulation: Cardiovascular Genetics. 2013 Apr; 6(2): 171-83.  PMID:23362303

D Mozaffarian, RN Lemaitre, IB King, X Song, H Huang, FM Sacks, EB Rimm, M Wang, DS Siscovick. Plasma phospholipid long-chain ω-3 fatty acids and total and cause-specific mortality in older adults: a cohort study.  Ann Intern Med. 2013 Apr 2;158(7):515-25. doi: 10.7326/0003-4819-158-7-201304020-00003. PMID:23546563

D Mozaffarian, MC de Oliveira Otto, RN Lemaitre, AM Fretts, G Hotamisligil, MY Tsai, DS Siscovick, JA Nettleton. trans-Palmitoleic acid, other dairy fat biomarkers, and incident diabetes: the Multi-Ethnic Study of Atherosclerosis (MESA). 2013-04-01. PMID:23407305

Common variation in fatty acid genes and resuscitation from sudden cardiac arrest. Johnson CO, Lemaitre RN, Fahrenbruch CE, Hesselson S, Sotoodehnia N, McKnight B, Rice KM, Kwok PY, Siscovick DS, Rea TD. Circ Cardiovasc Genet. 2012 Aug 1;5(4):422-9. doi: 10.1161/CIRCGENETICS.111.961912. Epub 2012 Jun 1. Erratum in: Circ Cardiovasc Genet. 2013 Feb;6(1):e1. PMID:22661490

Jensen RA, Sim X, Li X, Cotch MF, et. al.  Genome-wide association study of retinopathy in individuals without diabetes. PLoS One. 2013;8(2):e54232. doi: 10.1371/journal.pone.0054232.  PMID:23393555

Fretts AM, Mozaffarian D, Siscovick DS, Heckbert SR, McKnight B, King IB, Rimm EB, Psaty BM, Sacks FM, Song X, Spiegelman D, Lemaitre RN.  J Am Heart Assoc. 2013 Jan 31;2(1) PMID:23525429

Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from 15 cohorts. Nettleton JA, Hivert MF, Lemaitre RN, et. al. Am J Epidemiol. 2013 Jan 15;177(2):103-15. doi: 10.1093/aje/kws297. Epub 2012 Dec 19. Review. PMID:23255780

Holliday EG, Smith AV, Cornes BK, et al.  Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. PLoS One. 2013;8(1):e53830. doi: 10.1371/journal.pone.0053830.  PMID:23326517

AM Fretts, BV Howard, B McKnight, GE Duncan, SA Beresford, D Calhoun, AM Kriska, KL Storti, DS Siscovick. Modest levels of physical activity are associated with a lower incidence of diabetes in a population with a high rate of obesity: the strong heart family study. 2012-08-01 PMID:22723343

RN Lemaitre, C Sitlani, X Song, IB King, B McKnight, D Spiegelman, FM Sacks, L Djoussé, EB Rimm, DS Siscovick, D Mozaffarian. Circulating and dietary α-linolenic acid and incidence of congestive heart failure in older adults: the Cardiovascular Health Study. 2012-08-01. PMID:22743310

Fretts, A.M.,  Howard B.V.,  Siscovick D.S. Reply to D Allotey et al and SC Luncan. American Journal of Clinical Nutrition.  2012; 96: 446-448.   PMID:22821371

AM Fretts, BV Howard, B McKnight, GE Duncan, SA Beresford, M Mete, S Eilat-Adar, Y Zhang, DS Siscovick. Associations of processed meat and unprocessed red meat intake with incident diabetes: the Strong Heart Family Study. 2012-03-01. PMID:22277554

Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. Lemaitre RN, Tanaka T, Tang W, et. al. PLoS Genet. 2011 Jul;7(7):e1002193. PMID:21829377

Fatty acids in the de novo lipogenesis pathway and risk of coronary heart disease: the Cardiovascular Health Study. Wu JH, Lemaitre RN, Imamura F, King IB, Song X, Spiegelman D, Siscovick DS, Mozaffarian D. Am J Clin Nutr. 2011 Aug;94(2):431-8. PMID:21697077

A Dehghan, J Dupuis, M Barbalic, JC Bis, G Eiriksdottir, et. al. Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation 123, 731-8 (2011). PMID:21300955

Trans-palmitoleic acid, metabolic risk factors, and new-onset diabetes in U.S. adults: a cohort study. Mozaffarian D, Cao H, King IB, Lemaitre RN, Song X, Siscovick DS, Hotamisligil GS. Ann Intern Med. 2010 Dec 21;153(12):790-9. PMID:21173413

Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies. Nettleton JA, McKeown NM, Kanoni S, Lemaitre RN et. al. Diabetes Care. 2010 Dec;33(12):2684-91. PMID:20693352

AM Fretts, BV Howard, AM Kriska, NL Smith, T Lumley, ET Lee, M Russell, D Siscovick. Physical activity and incident diabetes in American Indians: the Strong Heart Study. 2009-09-01. PMID:19622672