Cardiovascular Health Research Unit

Susan R. Heckbert, MD, PhD

Professor, Epidemiology
Adjunct Professor, Department of Pharmacy
Affiliate Investigator, Group Health Research Institute

heckbertu.washington.edu

Education

MD, Case Western Reserve University, Cleveland, OH, 1981
MPH, Epidemiology, University of Washington, Seattle, WA, 1987
PhD, Epidemiology, University of Washington, Seattle, WA, 1990


Interests

Clinical epidemiology, with emphasis on cardiovascular disease.
Benefits and adverse effects associated with drug therapy.
Interaction of genetic susceptibility with medication use
Genetic associations with cardiovascular disease


Honors

BS with distinction, Stanford University, Stanford, CA
Phi Beta Kappa, Stanford University
Alpha Omega Alpha, Case Western Reserve University, Cleveland, OH
Chief Medical Resident, Harborview Medical Center, Seattle, WA
Upjohn Award for Clinical Ability and Humanitarian Concern, Harborview Medical Center
Charles A. Dana Foundation Fellow, Program in Ecogenetics
American Epidemiological Society


Publications

Floyd JS, Bis JC, Brody JA, Heckbert SR, Rice K, Psaty BM. GATM locus does not replicate in rhabdomyolysis study. Nature. 2014;513:E1-3. [Brief Communication]. PMID:25230668

Floyd JS, Sitlani CM, Wiggins, KL, Wallace E, Suchy-Dicey A, Carnethon MR, Siscovick DS, Sotoodehnia N, Heckbert SR, McKnight B, Rice K, Psaty BM. Variation in resting heart rate over four years and the risks of myocardial infarction and death among older adults. Heart, published online Sep 11, 2014. doi: 10.1136/heartjnl-2014-306046. PMID:25214500

Fretts AM, Mozaffarian D, Siscovick DS, Djousse L, Heckbert SR, King IB, McKnight B, Sitlani C, Sacks FM, Song X, Sotoodehnia N, Spiegelman D, Wallace ER, Lemaitre RN. Plasma phospholipid saturated fatty acids and incident atrial fibrillation: the Cardiovascular Health Study.  J Am Heart Assoc. 2014 Jun 26;3(3).  PMID:24970268

CL Avery, CM Sitlani, DE Arking, DK Arnett, JC Bis, E Boerwinkle, BM Buckley, YD Ida Chen, AJ de Craen, M Eijgelsheim, D Enquobahrie, DS Evans, I Ford, ME Garcia, V Gudnason, TB Harris, SR Heckbert, H Hochner, A Hofman, WC Hsueh, A Isaacs, JW Jukema, P Knekt, JA Kors, BP Krijthe, K Kristiansson, M Laaksonen, Y Liu, X Li, PW Macfarlane, C Newton-Cheh, MS Nieminen, BA Oostra, GM Peloso, K Porthan, K Rice, FF Rivadeneira, JI Rotter, V Salomaa, N Sattar, DS Siscovick, PE Slagboom, AV Smith, N Sotoodehnia, DJ Stott, BH Stricker, T Stürmer, S Trompet, AG Uitterlinden, C van Duijn, RG Westendorp, JC Witteman, EA Whitsel, BM Psaty. Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. 2014-02-01. PMID:23459443

Lin H, Sinner MF, Brody JA, Arking DE, Lunetta KL, Rienstra M, Lubitz SA, Magnani JW, Sotoodehnia N, McKnight B, McManus DD, Boerwinkle E, Psaty BM, Rotter JI, Bis JC, Gibbs RA, Muzny D, Kovar CL, Morrison AC, Gupta M, Folsom AR, Kääb S, Heckbert SR, Alonso A, Ellinor PT, Benjamin EJ; on behalf of the CHARGE Atrial Fibrillation Working Group. Targeted sequencing in candidate genes for atrial fibrillation: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Targeted Sequencing Study. Heart Rhythm. 2013 Nov 14. doi:pii: S1547-5271(13)01316-7. 10.1016/j.hrthm.2013.11.012.  PMID:24239840

KK Patton, SR Heckbert, A Alonso, H Bahrami, JA Lima, G Burke, RA Kronmal. N-terminal pro-B-type natriuretic peptide as a predictor of incident atrial fibrillation in the Multi-Ethnic Study of Atherosclerosis: the effects of age, sex and ethnicity.  Heart. 2013 Dec;99(24):1832-6. doi: 10.1136/heartjnl-2013-304724. Epub 2013 Oct 16. PMID:24131775

Smith NL, Blondon M, Wiggins KL, Harrington LB, van Hylckama Vlieg A, Floyd JS, Hwang M, Bis JC, McKnight B, Rice KM, Lumley T, Rosendaal FR, Heckbert SR, Psaty BM. Lower Risk of Cardiovascular Events in Postmenopausal Women Taking Oral Estradiol Compared With Oral Conjugated Equine Estrogens. JAMA Intern Med. 2013 Sep 30. doi: 10.1001/jamainternmed.2013.11074.  PMID:24081194

D Key, G Hart, N Smith, S Heckbert, J Floyd, K Wiggins, B Psaty. PS3-12: VDW Dashboards to Assure the Quality and Stability of Monthly Updates: The Heart and Vascular Health (HVH) Study Experience. 2013-09-01. PMID:24086032

Thacker EL, McKnight B, Psaty BM, Longstreth WT Jr, Sitlani CM, Dublin S, Arnold AM, Fitzpatrick AL, Gottesman RF, Heckbert SR. Atrial fibrillation and cognitive decline: a longitudinal cohort study. Neurology. 2013 Jul 9;81(2):119-25. doi: 10.1212/WNL.0b013e31829a33d1.  PMID:23739229

Blondon M, Wiggins KL, McKnight B, Psaty BM, Rice KM, Heckbert SR, Smith NL. The association of smoking with venous thrombosis in women. A population-based, case-control study. Thromb Haemost. 2013 May;109(5):891-6. doi: 10.1160/TH12-10-0732.  PMID:23467568

PN Jensen, EL Thacker, S Dublin, BM Psaty, SR Heckbert. Racial differences in the incidence of and risk factors for atrial fibrillation in older adults: the cardiovascular health study. J Am Geriatr Soc. 2013 Feb;61(2):276-80. doi: 10.1111/jgs.12085. Epub 2013 Jan 15. PMID:23320758

JP Piccini, MF Sinner, MA Greiner, BG Hammill, JD Fontes, JP Daubert, PT Ellinor, AF Hernandez, AJ Walkey, SR Heckbert, EJ Benjamin, LH Curtis. Outcomes of Medicare beneficiaries undergoing catheter ablation for atrial fibrillation. Circulation. 2012 Oct 30;126(18):2200-7. doi: 10.1161/CIRCULATIONAHA.112.109330. Epub 2012 Sep 26. PMID:23019293

Floyd JS, Heckbert SR, Weiss NS, Carrell DS, Psaty BM. Use of administrative data to estimate the incidence of statin-related rhabdomyolysis. JAMA. 2012;307:1580-1582. [Research Letter]  PMID:22511681

JP Piccini, BG Hammill, MF Sinner, PN Jensen, AF Hernandez, SR Heckbert, EJ Benjamin, LH Curtis. Incidence and prevalence of atrial fibrillation and associated mortality among Medicare beneficiaries, 1993-2007. Circ Cardiovasc Qual Outcomes. 2012 Jan;5(1):85-93. PMID:22235070

PN Jensen, K Johnson, J Floyd, SR Heckbert, R Carnahan, S Dublin. A systematic review of validated methods for identifying atrial fibrillation using administrative data. Pharmacoepidemiol Drug Saf. 2012 Jan;21 Suppl 1:141-7. PMID:22262600

JC Bis, M Kavousi, N Franceschini, A Isaacs, GR Abecasis, et.al. Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. Nat Genet 43, 940-7 (2011) PMID:21909108

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.  Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD, Verwoert GC, Hwang SJ, Pihur V, Vollenweider P, O'Reilly PF, Amin N, Bragg-Gresham JL, Teumer A, Glazer NL, Launer L, Zhao JH, Aulchenko Y, Heath S, et al. Nature. 2011 Sep 11;478(7367):103-9. PMID:21909115

RB Schnabel, KF Kerr, SA Lubitz, EL Alkylbekova, GM Marcus, MF Sinner, JW Magnani, PA Wolf, R Deo, DM Lloyd-Jones, KL Lunetta, R Mehra, D Levy, ER Fox, DE Arking, TH Mosley, M Müller-Nurasyid, TR Young, HE Wichmann, S Seshadri, DN Farlow, JI Rotter, EZ Soliman, NL Glazer, JG Wilson, MM Breteler, N Sotoodehnia, C Newton-Cheh, S Kääb, PT Ellinor, A Alonso, EJ Benjamin, SR Heckbert, Candidate Gene Association Resource (CARe) Atrial Fibrillation/Electrocardiography Working Group. Large-scale candidate gene analysis in whites and African Americans identifies IL6R polymorphism in relation to atrial fibrillation: the National Heart, Lung, and Blood Institute's Candidate Gene Association Resource (CARe) project. Circ Cardiovasc Genet. 2011 Oct;4(5):557-64. PMID:21846873

GM Marcus, A Alonso, CA Peralta, G Lettre, E Vittinghoff, SA Lubitz, ER Fox, YS Levitzky, R Mehra, KF Kerr, R Deo, N Sotoodehnia, M Akylbekova, PT Ellinor, DN Paltoo, EZ Soliman, EJ Benjamin, SR Heckbert, Candidate-Gene Association Resource (CARe) Study. European ancestry as a risk factor for atrial fibrillation in African Americans. Circulation. 2010 Nov 16;122(20):2009-15. PMID:21098467

S Debette, JC Bis, M Fornage, H Schmidt, MA Ikram, et. al. Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE Consortium. Stroke 41, 210-7 (2010). PMID:20044523

A Pfeufer, C van Noord, KD Marciante, DE Arking, MG Larson, AV Smith, KV Tarasov, M Müller, N Sotoodehnia, MF Sinner, GC Verwoert, M Li, WH Kao, A Köttgen, J Coresh, JC Bis, BM Psaty, K Rice, JI Rotter, F Rivadeneira, A Hofman, JA Kors, BH Stricker, AG Uitterlinden, CM van Duijn, BM Beckmann, W Sauter, C Gieger, SA Lubitz, C Newton-Cheh, TJ Wang, JW Magnani, RB Schnabel, MK Chung, J Barnard, JD Smith, DR Van Wagoner, RS Vasan, T Aspelund, G Eiriksdottir, TB Harris, LJ Launer, SS Najjar, E Lakatta, D Schlessinger, M Uda, GR Abecasis, B Müller-Myhsok, GB Ehret, E Boerwinkle, A Chakravarti, EZ Soliman, KL Lunetta, S Perz, HE Wichmann, T Meitinger, D Levy, V Gudnason, PT Ellinor, S Sanna, S Kääb, JC Witteman, A Alonso, EJ Benjamin, SR Heckbert. Genome-wide association study of PR interval. Nat Genet. 2010 Feb;42(2):153-9. PMID:20062060

DB Hancock, M Eijgelsheim, JB Wilk, SA Gharib, LR Loehr, et. al. Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. 2010-01-01. PMID:20010835

MA Ikram, S Seshadri, JC Bis, M Fornage, AL DeStefano, et. al. Genomewide association studies of stroke. N Engl J Med 360, 1718-28 (2009). PMID:19369658

SR Heckbert, KL Wiggins, NL Glazer, S Dublin, BM Psaty, NL Smith, WT Longstreth, T Lumley. Antihypertensive treatment with ACE inhibitors or beta-blockers and risk of incident atrial fibrillation in a general hypertensive population. Am J Hypertens. 2009 May;22(5):538-44. PMID:19265792

JC Bis, SR Heckbert, NL Smith, AP Reiner, K Rice, T Lumley, LA Hindorff, KD Marciante, DA Enquobahrie, SA Monks, BM Psaty. Variation in inflammation-related genes and risk of incident nonfatal myocardial infarction or ischemic stroke. Atherosclerosis 198, 166-173 (2008). PMID:17981284

SR Heckbert, G Li, SR Cummings, NL Smith, BM Psaty. Use of alendronate and risk of incident atrial fibrillation in women. Arch Intern Med. 2008 Apr 28;168(8):826-31. PMID:18443257