Cardiovascular Health Research Unit

Joshua C. Bis, PhD

Research Scientist


BS, Zoology, Lyman Briggs School, Michigan State University, East Lansing, MI, 1999
MS, Epidemiology, University of Washington, Seattle, WA, 2002
PhD, Epidemiology, University of Washington, Seattle, WA, 2007


Genomic Epidemiology
Rare variants & Sequence analysis
Subclinical atherosclerosis
Cardiovascular disease & risk factors
Neurological traits
Dementia & Alzheimer's disease
Drug-gene interactions


American Heart Association: Roger R. Williams Memorial Award for Genetic Epidemiology and the Prevention and Treatment of Atherosclerosis, 2010
CHARGE Consortium. Outstanding young investigator, 2012


Floyd JS, Bis JC, Brody JA, Heckbert SR, Rice K, Psaty BM. GATM locus does not replicate in rhabdomyolysis study. Nature. 2014;513:E1-3. [Brief Communication]. PMID:25230668

GM Peloso, PL Auer, JC Bis, A Voorman, AC Morrison, NO Stitziel, JA Brody, et. al. Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks. 2014-02-06. PMID:24507774

CL Avery, CM Sitlani, DE Arking, DK Arnett, JC Bis, E Boerwinkle, BM Buckley, YD Ida Chen, AJ de Craen, M Eijgelsheim, D Enquobahrie, DS Evans, I Ford, ME Garcia, V Gudnason, TB Harris, SR Heckbert, H Hochner, A Hofman, WC Hsueh, A Isaacs, JW Jukema, P Knekt, JA Kors, BP Krijthe, K Kristiansson, M Laaksonen, Y Liu, X Li, PW Macfarlane, C Newton-Cheh, MS Nieminen, BA Oostra, GM Peloso, K Porthan, K Rice, FF Rivadeneira, JI Rotter, V Salomaa, N Sattar, DS Siscovick, PE Slagboom, AV Smith, N Sotoodehnia, DJ Stott, BH Stricker, T Stürmer, S Trompet, AG Uitterlinden, C van Duijn, RG Westendorp, JC Witteman, EA Whitsel, BM Psaty. Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. 2014-02-01. PMID:23459443

JC Lambert, CA Ibrahim-Verbaas, JC Bis, et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. 2013-10-27. PMID:24162737

JC Bis, C DeCarli, AV Smith, F van der Lijn, F Crivello, et. al. Common variants at 12q14 and 12q24 are associated with hippocampal volume. Nat Genet 44, 545-51 (2012). PMID:22504421

JC Bis, M Kavousi, N Franceschini, A Isaacs, GR Abecasis, Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. Nat Genet 43, 940-7 (2011) PMID:21909108

A Dehghan, J Dupuis, M Barbalic, JC Bis, G Eiriksdottir, et. al. Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation 123, 731-8 (2011). PMID:21300955

S Debette, JC Bis, M Fornage, H Schmidt, MA Ikram, et. al. Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE Consortium. Stroke 41, 210-7 (2010). PMID:20044523

JC Bis, NL Glazer, BM Psaty. Genome-wide association studies of cardiovascular risk factors: design, conduct and interpretation. J Thromb Haemost 7 Suppl 1, 308-11 (2009). PMID:19630823

MA Ikram, S Seshadri, JC Bis, M Fornage, AL DeStefano, et. al. Genomewide association studies of stroke. N Engl J Med 360, 1718-28 (2009). PMID:19369658

JC Bis, SR Heckbert, NL Smith, AP Reiner, K Rice, T Lumley, LA Hindorff, KD Marciante, DA Enquobahrie, SA Monks, BM Psaty. Variation in inflammation-related genes and risk of incident nonfatal myocardial infarction or ischemic stroke. Atherosclerosis 198, 166-173 (2008). PMID:17981284