Cardiovascular Health Research Unit

Ken Rice, PhD

Associate Professor, Biostatistics

kenriceu.washington.edu

Education

BA, Mathematics, Churchill College, Cambridge University. Cambridge, UK, 1995
Diploma in Mathematical Statistics, Churchill College, Cambridge University. Cambridge, UK, 1998
PhD, Biostatistics, Churchill College, Cambridge University. Cambridge, UK, 2001


Interests

Statistical Methods


Honors

Scholarship award, Churchill College, Cambridge University, 1995
Cambridge University Wishart Prize for Statistics, 1998
Cambridge University Smith-Knight and Rayleigh-Knight Prize for Applied Mathematics Essay,
“Misclassification of Exposure in Case-Control Studies”, 2000
European Young Researcher Award to attend International Workshop on Statistics with Deficient
Data, Munich, 2000
European Young Researcher Award to attend Inaugural Meeting of the International Biometric
Society, Eastern Mediterranean Region, Athens, 2001


Publications

CM Sitlani, J Dupuis, KM Rice, F Sun, AN Pitsillides, LA Cupples, and BM Psaty. Genome-Wide Gene-Environment Interactions on Quantitative Traits using Family Data. In press at European Journal of Human Genetics. PMID:26626313

CM Sitlani, KM Rice, T Lumley, B McKnight, LA Cupples, CL Avery, R Noordam, BHC Stricker, EA Whitsel, and BM Psaty. Generalized estimating equations for genome-wide association studies using longitudinal phenotype data. Statistics in Medicine, 34:118-130, 2015. PMID:25297442

Floyd JS, Bis JC, Brody JA, Heckbert SR, Rice K, Psaty BM. GATM locus does not replicate in rhabdomyolysis study. Nature. 2014;513:E1-3. [Brief Communication]. PMID:25230668

Floyd JS, Sitlani CM, Wiggins, KL, Wallace E, Suchy-Dicey A, Carnethon MR, Siscovick DS, Sotoodehnia N, Heckbert SR, McKnight B, Rice K, Psaty BM. Variation in resting heart rate over four years and the risks of myocardial infarction and death among older adults. Heart, published online Sep 11, 2014. doi: 10.1136/heartjnl-2014-306046. PMID:25214500

CL Avery, CM Sitlani, DE Arking, DK Arnett, JC Bis, E Boerwinkle, BM Buckley, YD Ida Chen, AJ de Craen, M Eijgelsheim, D Enquobahrie, DS Evans, I Ford, ME Garcia, V Gudnason, TB Harris, SR Heckbert, H Hochner, A Hofman, WC Hsueh, A Isaacs, JW Jukema, P Knekt, JA Kors, BP Krijthe, K Kristiansson, M Laaksonen, Y Liu, X Li, PW Macfarlane, C Newton-Cheh, MS Nieminen, BA Oostra, GM Peloso, K Porthan, K Rice, FF Rivadeneira, JI Rotter, V Salomaa, N Sattar, DS Siscovick, PE Slagboom, AV Smith, N Sotoodehnia, DJ Stott, BH Stricker, T Stürmer, S Trompet, AG Uitterlinden, C van Duijn, RG Westendorp, JC Witteman, EA Whitsel, BM Psaty. Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. 2014-02-01. PMID:23459443

Smith NL, Blondon M, Wiggins KL, Harrington LB, van Hylckama Vlieg A, Floyd JS, Hwang M, Bis JC, McKnight B, Rice KM, Lumley T, Rosendaal FR, Heckbert SR, Psaty BM. Lower Risk of Cardiovascular Events in Postmenopausal Women Taking Oral Estradiol Compared With Oral Conjugated Equine Estrogens. JAMA Intern Med. 2013 Sep 30. doi: 10.1001/jamainternmed.2013.11074.  PMID:24081194

Blondon M, Wiggins KL, Van Hylckama Vlieg A, McKnight B, Psaty BM, Rice KM, Heckbert SR, Smith NL. Smoking, postmenopausal hormone therapy and the risk of venous thrombosis: a population-based, case-control study. Br J Haematol. 2013 Nov;163(3):418-20. doi: 10.1111/bjh.12508. Epub 2013 Aug 8. PMID:23927442

Blondon M, Wiggins KL, McKnight B, Psaty BM, Rice KM, Heckbert SR, Smith NL. The association of smoking with venous thrombosis in women. A population-based, case-control study. Thromb Haemost. 2013 May;109(5):891-6. doi: 10.1160/TH12-10-0732.  PMID:23467568

Common variation in fatty acid genes and resuscitation from sudden cardiac arrest. Johnson CO, Lemaitre RN, Fahrenbruch CE, Hesselson S, Sotoodehnia N, McKnight B, Rice KM, Kwok PY, Siscovick DS, Rea TD. Circ Cardiovasc Genet. 2012 Aug 1;5(4):422-9. doi: 10.1161/CIRCGENETICS.111.961912. Epub 2012 Jun 1. Erratum in: Circ Cardiovasc Genet. 2013 Feb;6(1):e1. PMID:22661490

A Fedorowski, N Franceschini, J Brody, C Liu, GC Verwoert, E Boerwinkle, D Couper, KM Rice, JI Rotter, F Mattace-Raso, A Uitterlinden, A Hofman, P Almgren, M Sjögren, B Hedblad, MG Larson, C Newton-Cheh, TJ Wang, KM Rose, BM Psaty, D Levy, J Witteman, O Melander. Orthostatic hypotension and novel blood pressure-associated gene variants: Genetics of Postural Hemodynamics (GPH) Consortium. 2012-09-01. PMID:22504314

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.  Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD, Verwoert GC, Hwang SJ, Pihur V, Vollenweider P, O'Reilly PF, Amin N, Bragg-Gresham JL, Teumer A, Glazer NL, Launer L, Zhao JH, Aulchenko Y, Heath S, et al. Nature. 2011 Sep 11;478(7367):103-9. PMID:21909115

Behavior of QQ-plots and genomic control in studies of gene-environment interaction.  Voorman A, Lumley T, McKnight B, Rice K.  PLoS One. 2011 May 12;6(5):e19416. PMID:21589913

A Dehghan, J Dupuis, M Barbalic, JC Bis, G Eiriksdottir, et. al. Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation 123, 731-8 (2011). PMID:21300955

Permutation and parametric bootstrap tests for gene-gene and gene-environment interactions.  Bůžková P, Lumley T, Rice K.  Ann Hum Genet. 2011 Jan;75(1):36-45. PMID:20384625

Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies. Nettleton JA, McKeown NM, Kanoni S, Lemaitre RN et. al. Diabetes Care. 2010 Dec;33(12):2684-91. PMID:20693352

Potential for revealing individual-level information in genome-wide association studies.  Lumley T, Rice K.  JAMA. 2010 Feb 17;303(7):659-60 PMID:20159874

S Debette, JC Bis, M Fornage, H Schmidt, MA Ikram, et. al. Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE Consortium. Stroke 41, 210-7 (2010). PMID:20044523

A Pfeufer, C van Noord, KD Marciante, DE Arking, MG Larson, AV Smith, KV Tarasov, M Müller, N Sotoodehnia, MF Sinner, GC Verwoert, M Li, WH Kao, A Köttgen, J Coresh, JC Bis, BM Psaty, K Rice, JI Rotter, F Rivadeneira, A Hofman, JA Kors, BH Stricker, AG Uitterlinden, CM van Duijn, BM Beckmann, W Sauter, C Gieger, SA Lubitz, C Newton-Cheh, TJ Wang, JW Magnani, RB Schnabel, MK Chung, J Barnard, JD Smith, DR Van Wagoner, RS Vasan, T Aspelund, G Eiriksdottir, TB Harris, LJ Launer, SS Najjar, E Lakatta, D Schlessinger, M Uda, GR Abecasis, B Müller-Myhsok, GB Ehret, E Boerwinkle, A Chakravarti, EZ Soliman, KL Lunetta, S Perz, HE Wichmann, T Meitinger, D Levy, V Gudnason, PT Ellinor, S Sanna, S Kääb, JC Witteman, A Alonso, EJ Benjamin, SR Heckbert. Genome-wide association study of PR interval. Nat Genet. 2010 Feb;42(2):153-9. PMID:20062060

MA Ikram, S Seshadri, JC Bis, M Fornage, AL DeStefano, et. al. Genomewide association studies of stroke. N Engl J Med 360, 1718-28 (2009). PMID:19369658

JC Bis, SR Heckbert, NL Smith, AP Reiner, K Rice, T Lumley, LA Hindorff, KD Marciante, DA Enquobahrie, SA Monks, BM Psaty. Variation in inflammation-related genes and risk of incident nonfatal myocardial infarction or ischemic stroke. Atherosclerosis 198, 166-173 (2008). PMID:17981284