Cardiovascular Health Research Unit

Nicholas L. Smith, PhD

Investigator, CHRU
Professor, Department of Epidemiology
Affiliate Investigator, Group Health Research Institute
Director, Seattle Epidemiology and Information Resource Center and the Vietnam Era Twin (VET) registry, VA Puget Sound Health Care System


MPH, Epidemiology and Biostatistics, University of California, Berkeley, CA, 1993
PhD, Department of Epidemiology, University of Washington, Seattle, WA, 1997


Venous Thromboembolism
Hormone Replacement Therapy


Epidemiology Outstanding Student Award and Scholarship, 1997


Smith NL, Blondon M, Wiggins KL, Harrington LB, van Hylckama Vlieg A, Floyd JS, Hwang M, Bis JC, McKnight B, Rice KM, Lumley T, Rosendaal FR, Heckbert SR, Psaty BM. Lower Risk of Cardiovascular Events in Postmenopausal Women Taking Oral Estradiol Compared With Oral Conjugated Equine Estrogens. JAMA Intern Med. 2013 Sep 30. doi: 10.1001/jamainternmed.2013.11074.  PMID:24081194

D Key, G Hart, N Smith, S Heckbert, J Floyd, K Wiggins, B Psaty. PS3-12: VDW Dashboards to Assure the Quality and Stability of Monthly Updates: The Heart and Vascular Health (HVH) Study Experience. 2013-09-01. PMID:24086032

Wheeler S, Moore K, Forsberg CW, Riley K, Floyd JS, Smith NL, Boyko EJ. Mortality among veterans with type 2 diabetes initiating metformin, sulfonylurea, or rosiglitazone monotherapy. Diabetologia. 2013;56:1934-1943. PMID:23797633

Sim X, Jensen RA, Ikram MK, et. al. Genetic loci for retinal arteriolar microcirculation. PLoS One. 2013 Jun 12;8(6):e65804. doi: 10.1371/journal.pone.0065804. Print 2013. PubMed PMID: 23776548; PMID:23776548

Blondon M, Wiggins KL, McKnight B, Psaty BM, Rice KM, Heckbert SR, Smith NL. The association of smoking with venous thrombosis in women. A population-based, case-control study. Thromb Haemost. 2013 May;109(5):891-6. doi: 10.1160/TH12-10-0732.  PMID:23467568

A Dehghan, J Dupuis, M Barbalic, JC Bis, G Eiriksdottir, et. al. Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation 123, 731-8 (2011). PMID:21300955

AM Fretts, BV Howard, AM Kriska, NL Smith, T Lumley, ET Lee, M Russell, D Siscovick. Physical activity and incident diabetes in American Indians: the Strong Heart Study. 2009-09-01. PMID:19622672

MA Ikram, S Seshadri, JC Bis, M Fornage, AL DeStefano, et. al. Genomewide association studies of stroke. N Engl J Med 360, 1718-28 (2009). PMID:19369658

SR Heckbert, KL Wiggins, NL Glazer, S Dublin, BM Psaty, NL Smith, WT Longstreth, T Lumley. Antihypertensive treatment with ACE inhibitors or beta-blockers and risk of incident atrial fibrillation in a general hypertensive population. Am J Hypertens. 2009 May;22(5):538-44. PMID:19265792

JC Bis, SR Heckbert, NL Smith, AP Reiner, K Rice, T Lumley, LA Hindorff, KD Marciante, DA Enquobahrie, SA Monks, BM Psaty. Variation in inflammation-related genes and risk of incident nonfatal myocardial infarction or ischemic stroke. Atherosclerosis 198, 166-173 (2008). PMID:17981284

SR Heckbert, G Li, SR Cummings, NL Smith, BM Psaty. Use of alendronate and risk of incident atrial fibrillation in women. Arch Intern Med. 2008 Apr 28;168(8):826-31. PMID:18443257