Cardiovascular Health Research Unit

Bruce Psaty, MD, PhD

Co-director, Cardiovascular Health Research Unit
Professor, Medicine
Professor, Epidemiology
Adjunct Professor, Health Services
Senior Investigator, Group Health Research Institute

psatyu.washington.edu

Education

PhD, English language and literature, Indiana University, Bloomington, IN, 1979
MD, Indiana University, School of Medicine, Indianapolis, IN, 1981
MPH, University of Washington, Seattle, WA, 1986


Interests

Cardiovascular epidemiology
Myocardial infarction and stroke
Venous thrombosis
Atrial fibrillation
Risk factors, including hypertension, dyslipidemia, and diabetes
Pharmacoepidemiology and drug safety
Genetics, genomics and pharmacogenetics
Epidemiological methods


Honors

Remington Methodology Lecturer, AHA Epidemiology and Prevention Council, 2004
School of Public Health and Community Medicine Outstanding Faculty Community Service Award, 2005
University of Washington Outstanding Public Service Award for work in drug safety, 2005
Ancel Keys Memorial Lectureship, American Heart Association National Meeting, 2009
Member, US Food and Drug Administration Science Board, 2011-
Member, National Heart, Lung, Blood Institute Advisory Council, 2012-
Designated Distinguished Scientist by the American Heart Association, 2013
Elected to the Institute of Medicine of the National Academies of Science, 2013


Publications

Floyd JS, Bis JC, Brody JA, Heckbert SR, Rice K, Psaty BM. GATM locus does not replicate in rhabdomyolysis study. Nature. 2014;513:E1-3. [Brief Communication]. PMID:25230668

Floyd JS, Sitlani CM, Wiggins, KL, Wallace E, Suchy-Dicey A, Carnethon MR, Siscovick DS, Sotoodehnia N, Heckbert SR, McKnight B, Rice K, Psaty BM. Variation in resting heart rate over four years and the risks of myocardial infarction and death among older adults. Heart, published online Sep 11, 2014. doi: 10.1136/heartjnl-2014-306046. PMID:25214500

Floyd JS, Psaty BM. The potential risks of expedited drug approvals for acute bacterial infections. JAMA Internal Medicine. 2014;174:1436-7. [Viewpoint]. PMID:25023994

RN Lemaitre, CO Johnson, S Hesselson, N Sotoodhenia, B McKnight, CM Sitlani, TD Rea, IB King, PY Kwok, A Mak, G Li, J Brody, E Larson, D Mozaffarian, BM Psaty, A Huertas-Vazquez, JC Tardif, CM Albert, LP Lyytikäinen, DE Arking, S Kääb, HV Huikuri, BP Krijthe, M Eijgelsheim, YA Wang, K Reinier, T Lehtimäki, SL Pulit, R Brugada, M Müller-Nurasyid, CH Newton-Cheh, PJ Karhunen, BH Stricker, P Goyette, JI Rotter, SS Chugh, A Chakravarti, X Jouven, DS Siscovick. Common variation in fatty acid metabolic genes and risk of incident sudden cardiac arrest. 2014-03-01. PMID:24418166

GM Peloso, PL Auer, JC Bis, A Voorman, AC Morrison, NO Stitziel, JA Brody, et. al. Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks. 2014-02-06. PMID:24507774

CL Avery, CM Sitlani, DE Arking, DK Arnett, JC Bis, E Boerwinkle, BM Buckley, YD Ida Chen, AJ de Craen, M Eijgelsheim, D Enquobahrie, DS Evans, I Ford, ME Garcia, V Gudnason, TB Harris, SR Heckbert, H Hochner, A Hofman, WC Hsueh, A Isaacs, JW Jukema, P Knekt, JA Kors, BP Krijthe, K Kristiansson, M Laaksonen, Y Liu, X Li, PW Macfarlane, C Newton-Cheh, MS Nieminen, BA Oostra, GM Peloso, K Porthan, K Rice, FF Rivadeneira, JI Rotter, V Salomaa, N Sattar, DS Siscovick, PE Slagboom, AV Smith, N Sotoodehnia, DJ Stott, BH Stricker, T Stürmer, S Trompet, AG Uitterlinden, C van Duijn, RG Westendorp, JC Witteman, EA Whitsel, BM Psaty. Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. 2014-02-01. PMID:23459443

Lin H, Sinner MF, Brody JA, Arking DE, Lunetta KL, Rienstra M, Lubitz SA, Magnani JW, Sotoodehnia N, McKnight B, McManus DD, Boerwinkle E, Psaty BM, Rotter JI, Bis JC, Gibbs RA, Muzny D, Kovar CL, Morrison AC, Gupta M, Folsom AR, Kääb S, Heckbert SR, Alonso A, Ellinor PT, Benjamin EJ; on behalf of the CHARGE Atrial Fibrillation Working Group. Targeted sequencing in candidate genes for atrial fibrillation: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Targeted Sequencing Study. Heart Rhythm. 2013 Nov 14. doi:pii: S1547-5271(13)01316-7. 10.1016/j.hrthm.2013.11.012.  PMID:24239840

KJ Mukamal, JB Wilk, ML Biggs, MK Jensen, JH Ix, JR Kizer, RP Tracy, SJ Zieman, D Mozaffarian, BM Psaty, DS Siscovick, L Djoussé. Common FABP4 Genetic Variants and Plasma Levels of Fatty Acid Binding Protein 4 in Older Adults. 2013-11-01. PMID:24043587

AM Matteini, J Li, EM Lange, T Tanaka, LA Lange, RP Tracy, Y Wang, ML Biggs, DE Arking, MD Fallin, A Chakravarti, BM Psaty, S Bandinelli, L Ferrucci, AP Reiner, JD Walston. Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults. 2013-10-29.  PMID:24182552

JC Lambert, CA Ibrahim-Verbaas, JC Bis, et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. 2013-10-27. PMID:24162737

HJ Westra, MJ Peters, T Esko, et. al. Systematic identification of trans eQTLs as putative drivers of known disease associations. 2013-10-01. PMID:24013639

Smith NL, Blondon M, Wiggins KL, Harrington LB, van Hylckama Vlieg A, Floyd JS, Hwang M, Bis JC, McKnight B, Rice KM, Lumley T, Rosendaal FR, Heckbert SR, Psaty BM. Lower Risk of Cardiovascular Events in Postmenopausal Women Taking Oral Estradiol Compared With Oral Conjugated Equine Estrogens. JAMA Intern Med. 2013 Sep 30. doi: 10.1001/jamainternmed.2013.11074.  PMID:24081194

D Key, G Hart, N Smith, S Heckbert, J Floyd, K Wiggins, B Psaty. PS3-12: VDW Dashboards to Assure the Quality and Stability of Monthly Updates: The Heart and Vascular Health (HVH) Study Experience. 2013-09-01. PMID:24086032

Sabater-Lleal M, Huang J, Chasman D, et. al. J. Multiethnic meta-analysis of genome-wide association studies in  >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. Circulation. 2013 Sep 17;128(12):1310-24. doi: 10.1161/CIRCULATIONAHA.113.002251.  PMID:23969696

Liu CT, Monda KL, Taylor KC, et. al. Genome-wide association of body fat distribution in African ancestry populations suggests new loci. PLoS Genet. 2013;9(8):e1003681. doi: 10.1371/journal.pgen.1003681. Epub 2013 Aug 15 PMID:23966867

Blondon M, Wiggins KL, Van Hylckama Vlieg A, McKnight B, Psaty BM, Rice KM, Heckbert SR, Smith NL. Smoking, postmenopausal hormone therapy and the risk of venous thrombosis: a population-based, case-control study. Br J Haematol. 2013 Nov;163(3):418-20. doi: 10.1111/bjh.12508. Epub 2013 Aug 8. PMID:23927442

Thacker EL, McKnight B, Psaty BM, Longstreth WT Jr, Sitlani CM, Dublin S, Arnold AM, Fitzpatrick AL, Gottesman RF, Heckbert SR. Atrial fibrillation and cognitive decline: a longitudinal cohort study. Neurology. 2013 Jul 9;81(2):119-25. doi: 10.1212/WNL.0b013e31829a33d1.  PMID:23739229

van Meurs JB, Pare G, Schwartz SM, Hazra A, Tanaka T, Vermeulen SH, Cotlarciuc I, Yuan X, Mälarstig A, Bandinelli S, Bis JC, Blom H, Brown MJ, Chen C, Chen YD, Clarke RJ, Dehghan A, Erdmann J, Ferrucci L, Hamsten A, Hofman A, Hunter DJ, Goel A, Johnson AD, Kathiresan S, Kampman E, Kiel DP, Kiemeney LA, Chambers JC, Kraft P, Lindemans J, McKnight B, Nelson CP, O'Donnell CJ, Psaty BM, Ridker PM, Rivadeneira F, Rose LM, Seedorf U, Siscovick DS, Schunkert H, Selhub J, Ueland PM, Vollenweider P, Waeber G, Waterworth DM, Watkins H, Witteman JC, den Heijer M, Jacques P, Uitterlinden AG, Kooner JS, Rader DJ, Reilly MP, Mooser V, Chasman DI, Samani NJ, Ahmadi KR. Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease. Am J Clin Nutr. 2013 Sep;98(3):668-76. doi: 10.3945/ajcn.112.044545. Epub 2013 Jul 3. PubMed PMID: 23824729. PMID:23824729

Monda KL, Chen GK, Taylor KC, et al. A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet. 2013 Jun;45(6):690-6. doi: 10.1038/ng.2608.  PMID:23583978

Sim X, Jensen RA, Ikram MK, et. al. Genetic loci for retinal arteriolar microcirculation. PLoS One. 2013 Jun 12;8(6):e65804. doi: 10.1371/journal.pone.0065804. Print 2013. PubMed PMID: 23776548; PMID:23776548

BM Psaty, C Sitlani. The Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium as a model of collaborative science. 2013-05-01. PMID:23549178

Wu, J.H.Y., Lemaitre,R.N., Manichaikul, A., Guan, W., Tanaka, T., Foy, M., Kabagambe, E.K., Djousse, L., Siscovick, D., Fretts, A.M.,  Johnson, C., King, I.B., Psaty, B.M., McKnight, B., Rich, S.S., Chen, Y.I., Nettleton, J.A., Tang, W.,  Bandinelli, S., Jacobs, D.R., Browning, B.L., Laurie, C.C., Gu, X., Tsai, M.Y., Steffen, L.M., Ferrucci, L., Fornage, M., Mozaffarian, D. Genome-Wide Association Study Identifies Novel Loci Associated With Concentrations of Four Plasma Phospholipid Fatty Acids in the De Novo Lipogenesis Pathway: Results from the CHARGE Consortium. Circulation: Cardiovascular Genetics. 2013 Apr; 6(2): 171-83.  PMID:23362303

Perry JR, Corre T, Esko T, et. al.  A genome-wide association study of early menopause and the combined impact of identified variants. Hum Mol Genet. 2013 Apr 1;22(7):1465-72. doi: 10.1093/hmg/dds551.  PMID:23307926

Blondon M, Wiggins KL, McKnight B, Psaty BM, Rice KM, Heckbert SR, Smith NL. The association of smoking with venous thrombosis in women. A population-based, case-control study. Thromb Haemost. 2013 May;109(5):891-6. doi: 10.1160/TH12-10-0732.  PMID:23467568

Jensen RA, Sim X, Li X, Cotch MF, et. al.  Genome-wide association study of retinopathy in individuals without diabetes. PLoS One. 2013;8(2):e54232. doi: 10.1371/journal.pone.0054232.  PMID:23393555

Fretts AM, Mozaffarian D, Siscovick DS, Heckbert SR, McKnight B, King IB, Rimm EB, Psaty BM, Sacks FM, Song X, Spiegelman D, Lemaitre RN.  J Am Heart Assoc. 2013 Jan 31;2(1) PMID:23525429

PN Jensen, EL Thacker, S Dublin, BM Psaty, SR Heckbert. Racial differences in the incidence of and risk factors for atrial fibrillation in older adults: the cardiovascular health study. J Am Geriatr Soc. 2013 Feb;61(2):276-80. doi: 10.1111/jgs.12085. Epub 2013 Jan 15. PMID:23320758

Holliday EG, Smith AV, Cornes BK, et al.  Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. PLoS One. 2013;8(1):e53830. doi: 10.1371/journal.pone.0053830.  PMID:23326517

Observational comparative effectiveness studies of drug therapies: high-quality answers or important clinical questions?: comment on "Comparative effectiveness of 2 β-blockers in hypertensive patients".  Floyd JS, Psaty BM.  Arch Intern Med. 2012 Oct 8;172(18):1412-14. PMID:22928183

A Fedorowski, N Franceschini, J Brody, C Liu, GC Verwoert, E Boerwinkle, D Couper, KM Rice, JI Rotter, F Mattace-Raso, A Uitterlinden, A Hofman, P Almgren, M Sjögren, B Hedblad, MG Larson, C Newton-Cheh, TJ Wang, KM Rose, BM Psaty, D Levy, J Witteman, O Melander. Orthostatic hypotension and novel blood pressure-associated gene variants: Genetics of Postural Hemodynamics (GPH) Consortium. 2012-09-01. PMID:22504314

Floyd JS, Heckbert SR, Weiss NS, Carrell DS, Psaty BM. Use of administrative data to estimate the incidence of statin-related rhabdomyolysis. JAMA. 2012;307:1580-1582. [Research Letter]  PMID:22511681

Floyd JS, Kaspera R, Marciante KD, Weiss NS, Heckbert SR, Lumley T, Wiggins KL, Tamraz B, Kwok PY, Totah RA, Psaty BM. A screening case-control study of drug-drug interactions in statin users: a new adverse effect of clopidogrel. Clinical Pharmacology & Therapeutics. 2012;91:896-904. PMID:22419147

JC Bis, M Kavousi, N Franceschini, A Isaacs, GR Abecasis, et.al. Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. Nat Genet 43, 940-7 (2011) PMID:21909108

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.  Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD, Verwoert GC, Hwang SJ, Pihur V, Vollenweider P, O'Reilly PF, Amin N, Bragg-Gresham JL, Teumer A, Glazer NL, Launer L, Zhao JH, Aulchenko Y, Heath S, et al. Nature. 2011 Sep 11;478(7367):103-9. PMID:21909115

Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. Lemaitre RN, Tanaka T, Tang W, et. al. PLoS Genet. 2011 Jul;7(7):e1002193. PMID:21829377

A Dehghan, J Dupuis, M Barbalic, JC Bis, G Eiriksdottir, et. al. Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation 123, 731-8 (2011). PMID:21300955

S Debette, JC Bis, M Fornage, H Schmidt, MA Ikram, et. al. Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE Consortium. Stroke 41, 210-7 (2010). PMID:20044523

A Pfeufer, C van Noord, KD Marciante, DE Arking, MG Larson, AV Smith, KV Tarasov, M Müller, N Sotoodehnia, MF Sinner, GC Verwoert, M Li, WH Kao, A Köttgen, J Coresh, JC Bis, BM Psaty, K Rice, JI Rotter, F Rivadeneira, A Hofman, JA Kors, BH Stricker, AG Uitterlinden, CM van Duijn, BM Beckmann, W Sauter, C Gieger, SA Lubitz, C Newton-Cheh, TJ Wang, JW Magnani, RB Schnabel, MK Chung, J Barnard, JD Smith, DR Van Wagoner, RS Vasan, T Aspelund, G Eiriksdottir, TB Harris, LJ Launer, SS Najjar, E Lakatta, D Schlessinger, M Uda, GR Abecasis, B Müller-Myhsok, GB Ehret, E Boerwinkle, A Chakravarti, EZ Soliman, KL Lunetta, S Perz, HE Wichmann, T Meitinger, D Levy, V Gudnason, PT Ellinor, S Sanna, S Kääb, JC Witteman, A Alonso, EJ Benjamin, SR Heckbert. Genome-wide association study of PR interval. Nat Genet. 2010 Feb;42(2):153-9. PMID:20062060

DB Hancock, M Eijgelsheim, JB Wilk, SA Gharib, LR Loehr, et. al. Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. 2010-01-01. PMID:20010835

JC Bis, NL Glazer, BM Psaty. Genome-wide association studies of cardiovascular risk factors: design, conduct and interpretation. J Thromb Haemost 7 Suppl 1, 308-11 (2009). PMID:19630823

MA Ikram, S Seshadri, JC Bis, M Fornage, AL DeStefano, et. al. Genomewide association studies of stroke. N Engl J Med 360, 1718-28 (2009). PMID:19369658

SR Heckbert, KL Wiggins, NL Glazer, S Dublin, BM Psaty, NL Smith, WT Longstreth, T Lumley. Antihypertensive treatment with ACE inhibitors or beta-blockers and risk of incident atrial fibrillation in a general hypertensive population. Am J Hypertens. 2009 May;22(5):538-44. PMID:19265792

JC Bis, SR Heckbert, NL Smith, AP Reiner, K Rice, T Lumley, LA Hindorff, KD Marciante, DA Enquobahrie, SA Monks, BM Psaty. Variation in inflammation-related genes and risk of incident nonfatal myocardial infarction or ischemic stroke. Atherosclerosis 198, 166-173 (2008). PMID:17981284

SR Heckbert, G Li, SR Cummings, NL Smith, BM Psaty. Use of alendronate and risk of incident atrial fibrillation in women. Arch Intern Med. 2008 Apr 28;168(8):826-31. PMID:18443257