Cardiovascular Health Research Unit

Rheem Totah, PhD

Associate Professor of Medicinal Chemistry, School of Pharmacy, University of Washington
Adjunct Associate Professor of Oral Biology, School of Dentistry, University of Washington

rtotahu.washington.edu

Education

BS, Chemistry, Birzeit University, 1995
MS, Medicinal Chemistry, University of Kansas, 2000
PhD, Medicinal Chemistry, University of Kansas, 2002


Interests

Drug Metabolism, interactions and toxicity
Drug and disease induced cardiotoxicity
Pharmacogenetics of cytochrome P450s enzymes


Honors

Highest Honor award for distinguished undergraduates, Birzeit University, Birzeit, Palestine, 1995
First Place award for best Predoctoral Research Presentation, ISSX. 2000
Graduate Student Honors Award, School of Pharmacy, University of Kansas. 2002
Irsay-Dahle Graduate Honor Award for Excellence in Medicinal Chemistry, University of Kansas, 2002
Elmer M., and Joy B., Plein Fellow for Excellence in Pharmacy Education, 2002-2004
PhRMA Foundation New Investigator in Pharmacology/Toxicology, 2005-2006


Publications

R Kaspera, BJ Kirby, T Sahele, AC Collier, ED Kharasch, JD Unadkat, RA Totah. Investigating the contribution of CYP2J2 to ritonavir metabolism in vitro and in vivo.  PMID:24973543

EA Evangelista, R Kaspera, NA Mokadam, JP Jones, RA Totah. Activity, inhibition, and induction of cytochrome P450 2J2 in adult human primary cardiomyocytes.  PMID:24021950

B Tamraz, H Fukushima, AR Wolfe, R Kaspera, RA Totah, JS Floyd, B Ma, C Chu, KD Marciante, SR Heckbert, BM Psaty, DL Kroetz, PY Kwok. OATP1B1-related drug-drug and drug-gene interactions as potential risk factors for cerivastatin-induced rhabdomyolysis.  PMID:23652407